Phytochemistry And Evaluation Of Antimicrobial Activity Of Garcinia Kola On Methicillin Resistant Staphylococcus Aureus And Escherichia Coli

ABSTRACT

The antibacterial activity of Garcinia kola seeds varieties extracted in ethanol and water  was tested against some selected clinical bacteria  isolates; Staphylococcus aureus, and  Escherichia coli  at concentrations of 10, 20, 30 ,40 mg/ml. Disc diffusion method was employed to determine the antimicrobial activity of the extracts against test microorganisms. The results showed that the seed ethanol extracts exhibited more antimicrobial activity at a concentration of 40 mg/ml, with zones of inhibition ranging from 12 to 22mm for ethanol. The aqueous (water) extracts showed zones of inhibition ranging from 12 to 20mm.The Minimum Inhibitory Concentration (MIC) showed antimicrobial activity at lowest concentration against Staphylococcus aureus. There were presence of phytochemical compounds such as Tannins, Saponins, Alkaloid and Phenol. The results imply that the ethanol and aqueous extracts of Garcinia kola seed posses strong antibacterial properties in the treatment of bacterial infection, and hence its potential as a useful chemotherapeutic agent in the treatment of bacterial infections in humans.