Effects Of Goko Cleanser Decoction On Some Biochemical Parameters Of Albino Wistar Rats

ABSTRACT

This study investigated the effect of Goko cleanser on some biochemical parameters in albino wistar rats. Rats were divided into 4 groups of 5 rats each. Group I, which is the control, was given normal rat feed and water only. Group II, III and IV were administered 10ml/kg body weight, 15ml/kg body weight and 20ml/kg body weight of Goko cleanser respectively for 28 days. The result of this study showed that in Group III there was a significant (p<0.05) increase in the level of activity of the liver enzyme aspartate amino transferase (AST) (58.6±7.79 IU/I), when compared to the value of the normal group (40.70±2.49mg/l). Group IV showed significant decrease (p>0.05) in the concentration of total bilirubin (TB) (0.26±0.7 mg/l) when compared to the normal control in (0.44±0.19 mg/l). The concentration of Total Protein (TP), Alanine amino transferase (ALT), Alanine phosphatase (ALP) in Groups II, III, IV showed no significant differences when compared to the control (Group I). Group II showed significant increase (p<0.05) in the concentration of super dismutase (SOD) (3.11±1.68IU/I) when compared to the normal control (1.26± 0.95 IU/I). Group II, III, IV showed no significant difference in catalase activity when compared to the normal group. The administration of Goko cleanser to Group III had a significant increase (p<0.05) in creatinine level (1.15±0.015mg/dl) when compared to control (1.01±0.09 mg/dl) while Group IV showed significant (p>0.05) decrease in creatinine level (0.87±0.07 mg/dl) when compared to control (1.61±0.09mg/l). The concentration of urea (44.1±3.37 mg/dl) in Group IV showed significant increase (p<0.05) when compared to the normal (25.39±4.26 mg/dl).  Results obtained from this study seem to suggest that Goko cleanser may have some hepatoprotective property and may not be safe for use at high doses.